| Sadler | community in E Rockingham County served by post office, 1898-1910. |
| Safe | community in SW Duplin County served by post office, 1888-1903. Name derived from the fact that the first postmaster, Jacob Carr, operated a store and therein had a large safe, the only one in the area. |
| Sag Branch | rises in W Haywood County and flows NW into Caldwell Fork. |
| Sage Path | site of early settlement on the E end of Bogue Banks, S Carteret County. Storms drove out early settlers until the settlement of Salter Path, which see. |
| Sage Rock | peak in W Yancey County on Sevenmile Ridge near the head of Murphy Branch. |
| Sages Ordinary | See Holly Ridge. |
| Saginaw | See Pineola. |
| Sago | community in central Mecklenburg County served by post office, 1891-1902. |
| Sahara of North Carolina | See Sandhills. |
| Sahlee Creek | rises in N Swain County and flows SE into Deep Creek. |