| Sassafras Mountain | on the Transylvania County, N.C.-Pickens County, S.C., line S of the head of South Prong [Glady Fork]. Alt. 3,554. |
| Sassafras Ridge | extends NE from Bee Gap to Willie Knob in SW Graham County. |
| Sassafras Ridge | E Haywood County between Buckeye Cove and Beaverdam Creek. |
| Sassafras Ridge | S Macon County between Nantahala River and Nantahala Mountains. |
| Sassafras Ridge | elevated ground in E Washington County SW of the community of Scuppernong. The name appears in county records as early as 1868. |
| Sassarixa Swamp | rises in W Johnston County and flows SE into Black Creek. |
| Sasseenohla | See Big Bald. |
| Sassers Mill | community in NW Jones County on Heath Mill Run. |
| Sassers Millpond | N Wayne County on Great Swamp near Aycock Millpond. Fishing, boating; open to public. |
| Satterfield Creek | rises in W Person County and flows NE into Storys Creek. |