| Sawyersville | community in W Randolph County served by post office, 1849-1905. |
| Saxapahaw | community in SE Alamance County on Haw River. Named for the Sissipahaw Indians, who once lived in the area. A yarn mill was est. there in 1849. |
| Saxapahaw River | See Haw River. |
| Saxon | community in E Stokes County served by post office, 1891-1912. |
| Scale Creek | rises in NE Onslow County and flows SW into Northeast Creek. |
| Scalesville | community in N Guilford County. Named for the Scales family of Guilford and Rockingham Counties. |
| Scaly Mountain | S Macon County between the head of Middle Creek and the head of Piney Knob Fork. Alt. 4,804. |
| Scaly Mountain | community in S Macon County on Middle Creek. |
| Scaly Ridge | SE Clay County between Tallulah River and Beech Creek. |
| Scapecat Branch | rises in S Haywood County and flows W into Little East Fork Pigeon River. |