| Sidney | community in E Beaufort County. |
| Sidney | town in SW Columbus County. Inc. 1881, but long inactive in municipal affairs. |
| Sigmonsburg | See Glen Alpine. |
| Signal Bald | peak on the Clay-Macon County line. Alt. 5,275. |
| Signal Pole Hill | SW Cherokee County on SE end of Pack Mountain. Alt. 3,459. |
| Sikes Branch | rises in W Carteret County and flows approx. 2 mi. S and E to join East Prong in forming Sanders Creek. |
| Silas Creek | rises in NW Ashe County and flows SE into North Fork New River. |
| Silas Creek | rises in SW Beaufort County and flows N into Chocowinity Bay, Pamlico River. |
| Silas Creek | rises in NW Forsyth County and flows SW into Muddy Creek. Known earlier as Spangenberg Creek for Bishop August G. Spangenberg, who led a surveying party from Edenton to the Blue Ridge Mountains in 1752 in search of a suitable site for a Moravian settlement. Spangenberg Creek appears as Strangenbergs Creek on the Collet map, 1770, and as Spanking Back on the Price map, 1808. By 1833, when the MacRae map appeared, it was called Silas Creek. Reynolda Lake is on Silas Creek. |
| Silas Creek | community in N Ashe County. Alt. approx. 2,740. |