| Sandy Run Township | former township in SW Cleveland County, now township no. 7. |
| Sandy Springs | community in SW Rutherford and SE Polk Counties. A post office operated there, 1876-1908. |
| Sandycross | community in SE Gates County served by post office, 1884-1906. |
| Sanford | city and county seat, central Lee County. Laid out about 1872. Inc. 1874. Said to have been named for Col. C. O. Sanford, engineer for the Chatham Railroad. Jonesboro, which see, merged with Sanford in 1947. Produces bricks, pottery, lumber, electrical parts, primary metals, sheet-metal working, apparel, industrial machinery, furniture, insecticides, and cosmetics. Alt. 375. |
| Sans Souci | community in SE Bertie County. The name of an early plantation, which in French means "without care or worry." Long site of cable-drawn ferry. |
| Santeetlah | community in central Graham County on Santeetlah Lake. The former post office there, 1906-30, was called Millsaps. |
| Santeetlah Creek | rises in W Graham County and flows E into Santeetlah Lake. Name said to have meant "blue waters" in Cherokee, but Mooney's glossary says the Indians did not recognize or understand the name, insisting it was given to the creek by white men. They called the creek Nayuhi geyuni (sandplace stream), and Little Santeetlah Creek was known by them as Tsundaniltiyi |
| Santeetlah Gap | W central Graham County approx. ¾ mi. W of Funnel Top. |
| Santeetlah Lake | central Graham County, was formed in 1928 by a dam on Cheoah River. Covers 2,580 acres, with a shoreline of 105 mi. Max. depth 240 ft. Alt. 1,940. Used for power, fishing, and boating. |
| Santeetlah Wildlife Management Area | in W Graham County. 37,168 acres, operated by the state of North Carolina on U.S. Forest Service lands. Principal wildlife: bear, boar, deer, raccoon, and trout. |