| Sardis | community in S Mecklenburg County. Sardis Presbyterian Church was organized there in 1790. |
| Sardis | See Hudson. |
| Sarecta | area in central Duplin County on Northeast Cape Fear River. Settled about 1736 under the direction of Henry McCulloch of London. Est. 1787 as Sarecto; long inactive in municipal affairs. Alt. 67. Named for Soracte Mountain in Italy, near Rome, on which a temple to Apollo stood in ancient times. Often referred to as Soracte in colonial records. Served by post office, 1830-1903. |
| Sarem | community in W central Gates County; named for the ancient name for Salisbury, England. Alt. 34. A school for Indians was in operation there in 1712, and it was a preaching station for Rev. Clement Hall of Edenton in the 1750s. |
| Sarem Creek | rises in S Gates County and flows SE into Chowan River. Appears on the Collet map, 1770, where the modern Cole Creek is shown with the same name. |
| Sarvis Gap | NE Mitchell County between Wiles Creek and Lyddies Creek. |
| Sarvis Ridge | NE Mitchell County between Wiles Creek and Lyddies Creek. |
| Sasnett Mill Branch | rises in central Edgecombe County and flows SW into Cokey Swamp. |
| Sassafras Branch | rises in central Cherokee County and flows SE into Colvard Creek. |
| Sassafras Branch | rises in SE Clay County and flows SE into Tallulah River. |