| Second Creek | rises in E Tyrrell County and flows SE into Alligator River. Called Third Creek on the Collet map, 1770. Approx. 4½ mi. long and ¾ mi. wide at its mouth. |
| Second Creek | rises in N central Tyrrell County S of community of Pleasant View and flows W into Scuppernong River approx. 2¾ mi. S of town of Columbia. An old Indian village of uncertain tribal affiliation, Mequopen, is shown at the mouth of the creek on the De Bry map, 1590. Name means "red tribes" or "where there are red tribes." |
| Second Creek | community on the creek of the same name in N central Tyrrell County. |
| Second Creek | See North Second Creek; South Second Creek; Back Creek. |
| Second Creek Bluff | at the mouth of Second Creek in E Tyrrell County. |
| Second Creek Point | E Tyrrell County, extends from the mainland into Alligator River near the mouth of Second Creek. |
| Second Falls | the middle of a series of three waterfalls on Yellowstone Prong, S Haywood County. |
| Second Hurricane Branch | rises in E Swain County and flows SW into Yalaka Creek. |
| Second Potts Creek | rises in W Davidson County and flows S into High Rock Lake on Yadkin River. Appears on the Collet map, 1770, as Potts Creek. |
| Secotan | an Indian village once located on the S side of Pamlico River in what is now E Beaufort County in the vicinity of Hobucken; visited by John White and other explorers based on Roanoke Island in the sixteenth century. The name meant "town at the bend of a river." Appears as Secoton on the White map, 1585; as Secota on the De Bry map, 1590; and as Secotan on the Velasco map, 1611. See also Seco. |