| Sedalia | community in E Guilford County. The Alice Freeman Palmer Memorial Institute, a junior college and high school for African American women est. 1901, operated there until 1960s. Campus now a State Historic Site. |
| Sedgefield | community in W central Guilford County. Named for the fields of sedge (grasslike plants) in the vicinity. English-style inn opened 1927. Golf course hosts national tournaments. |
| Sedges Garden | community in N central Forsyth County. |
| See Off Mountain | S central Transylvania County between Dunn Creek and Haunty Branch. Alt. 3,080. |
| See-noh-ya | See Black Mountains. |
| Seed Cane Creek | rises in E Surry County and flows SW into Ararat River. |
| Seedbed of the Colony | See Salmon Creek. |
| Seeoff | community in SE Transylvania County. |
| Seeshore | community in S Transylvania County on a tributary of Carson Creek. |
| Sega Lake | in central Transylvania County on Graham Creek. Covers ¼ acre, with a max. depth of 10 ft. |